Today, Orano is continuing and speeding up its efforts to develop innovative solutions to support its existing value creation models.
Orano Med and its partner RadioMedix have received FDA* approval in the United States to initiate Phase 1 clinical trials on AlphaMedixTM, a development therapy for patients with neuroendocrine tumors (NET) that express specific receptors, known as somatostatin receptors. AlphaMedixTM made of a peptide analogous to somatostatin, which makes it possible to target tumour cells. Radio-marked with lead-212 (212Pb), it will make it possible, during anti-proliferation, to kill cancerous cells while limiting the damage to the surrounding healthy cells.
The objective of Phase 1 is to assess the tolerance, biodistribution and preliminary efficacy of AlphaMedixTM in adult patients with neuroendocrine tumors, by gradually increasing treatment doses. AlphaMedixTM will be produced entirely by Orano Med teams in the DDPU in Plano (Texas), before being sent to a clinical center in Houston specialised in this type of tumour. Patients will be treated under the responsibility of RadioMedix.
*Food and Drug Administration